new and novel treatment of opioid dependence: nigella sativa 500 mg

Opioid dependence is one of the major social and psychiatric problem of society. Unfortunately there is no non opiate treatment available. For centuries man has used plants for their healing proprieties. These plants play a fundamental part in all treatment modalities, both ancient and modern. This study was conducted to find non opiate treatment for opiate withdrawal. Total 35 known addicts of opiates were included in the study. This study was based on DSM IV criteria for opioid dependence. This study demonstrates that non opioid treatment for opioid addiction decreases the withdrawal effects significantly. It further demonstrates that there are no changes in physiological parameters of subjects during treatment [BP, Pulse rate etc.]. There is increased appetite but no significant weight gain in the subjects. Non opioid drug Nigella sativa is effective in long term treatment of opioid dependence. It not merely cures the opioid dependence but also cures the infections and weakness from which majority of addicts suffer

Association of leukocyte count with albumin excretion in type 2 diabetes mellitus

In type 2 diabetes Mellitus albumin excretion rate correlates with leukocyte count. One of the major components of chronic sub clinical inflammation associated with both insulin resistance and other sclerosis. The aim of this study was to determine the relationship between leukocyte count and Albumin excretion in patients with type 2 diabetes Mellitus. A prospective study conducted on patients with type 2 diabetes during 2004 at BMSI Jinnah Post graduate Medical Centre Karachi. A total of 100 subjects of either sex were included, out of which 75 type 2 diabetics were selected from diabetic clinic Jinnah post graduate Medical Centre Karachi and 25 non diabetics as control from general population. Each subject was interviewed, examined and investigated for blood pressure measurements, body weight, fasting serum glucose urinary volume, urinary albumin, albumin creatinine ratio, urinary albumin excretion and leukocyte count. Patients having acute illness and proteinuria due to cardio vascular disease and other causes were excluded. Leukocyte count was significantly high [P<0.001] in all patient groups as compared to control group, also it shows significant increase in smoker diabetics as compared to non smoker diabetics. A strong relation ship was found between leukocyte count and albumin excretion r =0.786, P< 0.001 in type 2 diabetes Mellitus. Albumin excretion rate correlates with leukocyte count in patients with type 2 diabetes Mellitus

Role of Nigella Sativa in opioid dependence treatment

Opioid dependence is one of the major social and psychiatric problem of society. Unfortunately there is no non-opiate treatment available. This study was conducted to find out the role of Nigella Sativa as a potential non-opiate treatment for opiate withdrawal. The study was conducted at the Department of Pharmacology, University of Karachi and Drug Rehabilitation Centre, R.H.C., Murad Memon Goth, Karachi. The study was based on DSM IV criteria for opioid dependence. Nigella Sativa 250 mg is found effective in long-term management of opioid dependence

Effects of diazepam and promethazine on uterine contractions induced by prostaglandin E2 [PGE2]

This study was conducted at Basic Medical Sciences Institute, Jinnah Post Graduate Medical Center, Karachi. It was done to observe the inhibitory effects of diazepam and promethazine, on uterine contractions induced by prostaglandin E2 [PGE.2]. The drug interaction, in vitro, proved that both diazepam and promethazine are tocolytic in vitro

Trichobezoar and gastric polyps: a rare association

A 10 year old female child presented with upper abdominal pain and huge abdominal mass in epigastrium extending to both hypochondria and umbilical regions. Investigations revealed a trichobezoar with gastric polyps. At operation, a large trichobezoar occupying almost whole of the stomach was removed along with gastric polyps. Biopsy suggested hyperplastic polyps